Quick Facts

Dr. Marty Ross, MD
Dr. Ross's Expert Review
Ashwagandha is an herb I use often in my care regimens in my Seattle practice. It is an Ayurvedic adaptogen, which means it supports the ability to withstand stress.
Here is what chronic stress does. When the adrenal system is working right, it releases hydrocortisone, adrenaline, and mineral-regulating hormones in correct amounts. Under chronic stress that regulation goes out of balance, and the result is low energy and stamina, immune dysfunction, low thyroid function, increased inflammation, and at times anxiety. The research and my own experience both point the same direction: ashwagandha supports healthy balance in stress.
There is real science here. Controlled trials show reductions in perceived stress and anxiety scores and in morning cortisol. Animal research adds that it supports normal inflammatory cytokine levels, thyroid hormone levels, and white blood cell function. The exact mechanisms are not fully known. The clinical results are what I rely on.
How I use it: this is a daytime adaptogen. I typically have people take it in the morning and early afternoon, and I do not find it overstimulating the way some adrenal herbs are. Some colleagues prefer Siberian ginseng, licorice, or rhodiola, but I find those too energetically hot for the people I work with. Ashwagandha is neutral.
Not for pregnancy. And if insomnia worsens on it, the afternoon dose is the one to trim first. This is a steady workhorse, not a fast-acting agent, and I tell people to judge its effects over weeks.
How I Use It in My Practice
I use ashwagandha as ongoing stress support, 2 capsules in the morning and 2 more between 1 and 2 pm. If someone’s insomnia worsens on it, I cut the afternoon amount back to 1 capsule rather than dropping the herb. I reach for it when the picture includes low stamina, stress hormone imbalance, and stress-driven inflammation. I judge its effect over a month or two and I keep it running as long as the medical or psychologic stress remains high.
The Research, in Dr. Ross's Words
The ashwagandha literature is one of the better developed adaptogen bodies of evidence. Multiple controlled trials in adults report reductions in perceived stress and anxiety scores, with parallel drops in morning cortisol, the hormone signature you would expect if the herb is working on the stress response system itself. One trial went as low as 125 mg a day and still saw effects on stress measures.
Two meta-analyses strengthen the picture. One pooled the stress and anxiety trials and found significant effects on perceived stress, anxiety scores, and cortisol compared to placebo. The other looked at sleep and found small but real improvements overall, stronger in people with diagnosed insomnia, at higher doses, and with longer use, eight weeks or more.
The limits are worth naming. Most trials are small to moderate, and the sleep effects are modest, not sedative. But the direction is consistent, the mechanism is plausible, and the trials report good tolerability. That combination is rarer in this field than people expect. I use it with confidence for stress support and watch the sleep benefits as a secondary gain, which is close to how the trials frame it themselves.
Controlled trials show reductions in perceived stress and anxiety scores and in morning cortisol. Animal research adds that it supports normal inflammatory cytokine levels, thyroid hormone levels, and white blood cell function. The exact mechanisms are not fully known.
References
Supplement Facts
| Amount Per Serving | Amount | |
|---|---|---|
Organic Ashwagandha (Withania somnifera) root | 800 mg | |







