ongoing support
Gut & Digestive Health
Chewable deglycyrrhizinated licorice (DGL) with glycine from Integrative Therapeutics that supports a healthy stomach and intestinal mucosal lining and soothes occasional digestive discomfort.
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Quick Facts
Key Ingredients
Calories 10
Total Carbohydrate 2 g
Third-party Testing
Dietary
Dairy-free
Gluten-free
Vegan
Vegetarian
Written by
Dr. Marty Ross, MD
Updated
September 24, 2026
Dr. Ross's Expert Review
The stomach and upper gut have a tough job. They hold acid strong enough to start digestion, and they have to protect their own lining from it at the same time. When that mucous barrier gets thin, people feel it: discomfort after coffee, spicy food, or fried meals. Rhizinate is one of the first supports I reach for in that situation.
It is a simple formula done well. Each chewable tablet carries deglycyrrhizinated licorice, DGL for short, plus glycine. DGL is licorice with the glycyrrhizin removed, which matters, because glycyrrhizin is the part that can raise blood pressure. What is left supports the mucous lining of the stomach and upper intestinal tract. Glycine adds its own soothing, cytoprotective qualities and supports the mucosal barrier.
I like the chewable form on purpose. Chewing mixes the tablet with saliva, so the DGL coats the throat and stomach lining on the way down instead of bypassing it. For people who want the same formula without fructose, there is a fructose-free version of this same product.
I am candid about what DGL is and is not. It supports and soothes the lining; it does not replace a workup for ongoing digestive problems. Used the way I use it, as part of a gut regimen, it is a reliable product.
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. Dr. Ross has a financial relationship with the Femologist store, where this product is sold.
How I Use It in My Practice
I use Rhizinate as ongoing support for people whose stomach lining needs help during a gut regimen, and during courses of medicines or herbs that stir up the stomach. I recommend two chewable tablets before irritating supplements or medications or before meals and bed up to 4 times a day. My recommendation differs from the manufacturers, so you should discuss it with your physician first. I have people chew them well rather than swallowing, so the DGL contacts the lining on the way down. For people avoiding fructose, I use the fructose-free version of the same formula instead. If someone is pregnant, nursing, or taking prescription medicines, they should discuss using it with their physician first.
This reflects Dr. Ross's clinical experience and is educational, not medical advice. Work with your treating physician before starting, stopping, or changing any supplement or medication.
The Research, in Dr. Ross's Words
In my research review, the two ingredients have similar health support. The human work on DGL is older but real. A double-blind trial from 1974 looked at DGL in gastric ulcer, and a 1978 study found DGL reduced aspirin-related mucosal damage in both animals and people on aspirin. More recently, randomized trials of a standardized DGL extract found it eased functional dyspepsia symptoms, and a 2025 phase III trial found better and earlier resolution of heartburn and regurgitation complaints than placebo.
The glycine research is mechanistic based on laboratory work. A 2003 review described glycine’s cytoprotective effects on the gastric mucosa, a 2010 study showed glycine protecting human intestinal epithelial cells from oxidative damage, and a 2016 paper tied glycine to tight-junction proteins that hold the mucosal barrier together.
Limits: several of these papers studied ulcer or dyspepsia patients rather than healthy users, the older trials predate modern methods, and none tested this exact chewable form. I read the combined evidence as reasonable support for mucosal and comfort effects.
References
From:
Integrative Therapeutics
Rhizinate is deglycyrrhizinated licorice (DGL) in a chewable formula for soothing digestive relief. PROVIDES SOOTHING DIGESTIVE RELIEF: The stomach maintains an acidic pH that helps to initiate digestion and promote microbial defense, yet its epithelial tissues must simultaneously be shielded against harsh acidic conditions. The stomach's protective mucin barrier must be intact in order to protect stomach health and comfort. HELPS RELIEVE OCCASIONAL STOMACH DISCOMFORT: Rhizinate works by stimulating natural protective factors in the digestive tract that help relieve occasional stomach discomfort. Rhizinate contains less than 1% glycyrrhizin which may elevate blood pressure in some individuals.
Directions of Use
Chew 3 tablets after food in the morning. Chew 3 tablets after food in the evening, or as recommended by a healthcare professional.
Does not contain
artificial-colors
dairy
gluten
soy
wheat
If you are pregnant, nursing, or taking any medications, consult a healthcare practitioner before use. Keep out of reach of children. Safety sealed with inner seal. Do not use if seal is broken or missing. Keep tightly closed. Store at room temperature. Avoid excessive heat and direct sunlight.
Excerpted from Integrative Therapeutics's product information. These statements have not been evaluated by the Food and Drug Administration.
Supplement Facts
Serving Size: 3 Chewable Tablets
Servings Per Container: 33
| Amount Per Serving | Amount | |
|---|---|---|
Calories | 10 | |
Total Carbohydrate | 2 g | |
Total Sugars | 1 g | |
Includes 1 g Added Sugars | ||
Glycine | 150 mg | |
GutGuardâ„¢ Deglycyrrhizinated Licorice (DGL) (Glycyrrhiza spp.) Root Extract | 75 mg | |
†Daily Value (DV) not established.
** Daily Value (DV) not established. | ||
Common Questions about Rhizinate
Answers are general educational information, not medical advice for your situation.
Rhizinate
By Integrative Therapeutics
From $15.50 · Save 10% with code MARTYROSS10
Rhizinate (Fructose Free)
The fructose-free version of this same DGL and glycine formula.
Multi-Biome
Probiotics & Prebiotics category; fits gut regimens alongside mucosal support.
