ongoing support
Bartonella Support
Biofilm Disruptors
Boluoke is a standardized lumbrokinase enzyme supplement from Canada RNA that supports healthy circulation, helps maintain balanced coagulation and fibrinolysis, and supports the breakdown of fibrin in biofilms and fibrin-germ nests.
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MARTYROSS10
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Quick Facts
Key Ingredients
Proprietary earthworm protein extract 20 mg
Third-party Testing
Dietary
GMO-free
Written by
Dr. Marty Ross, MD
Updated
September 24, 2026
Dr. Ross's Expert Review
Boluoke is the brand of lumbrokinase I have used the longest in my practice. Lumbrokinase is a group of fibrin-dissolving enzymes extracted from earthworms, and Boluoke standardizes each acid-resistant capsule to 20 mg of enzyme at 300,000 lumbrokinase units. The capsule design matters. Lumbrokinase can be inactivated by stomach acid, so these capsules are built to dissolve in the small intestine instead.
Where it fits
Three things come up again and again in my conversations with patients: circulation that feels sluggish, biofilm-related concerns and possible fibrin-germ nests. Fibrin is a protein the body uses for clotting, and it is also described in the literature as a scaffold that germs can hide in. Using fibrin, germs can hide in biofilms and in fibrin-germ nests. Lumbrokinase supports the body’s natural breakdown of fibrin. That is why I use Boluoke as part of broader wellness regimens; the working idea is that supporting healthy fibrin balance lets the rest of a regimen do its job.
The research
The enzyme was first extracted and characterized from Lumbricus rubellus in the 1990 paper by Mihara and colleagues, and proteomic work has since identified the specific enzymes responsible. A 2023 study found lumbrokinase supports fibrin breakdown without activating plasminogen, a detail the study authors highlight. Much of the clinical data is older hospital work, and the newer trials in chronic illness are still underway. I am candid about that gap and lean on mechanism plus what I see in practice.
How I approach dosing
One capsule one to two times a day on an empty stomach is my usual starting point. For more pronounced circulation concerns I have used 2 capsules two times a day. The manufacturer lists a child dose of 1 capsule per 17 pounds of body weight per day, something I only consider with the child’s physician on board. This is not for people with bleeding risks, before surgery, or during pregnancy, and anyone on blood thinners needs physician supervision.
The bottom line
Enzymes are tools, not stand-alone treatments. Used well, inside a full regimen, Boluoke is a dependable tool for fibrin-germ nests and biofilm support.
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. Dr. Ross has a financial relationship with the Femologist store, where this product is sold.
How I Use It in My Practice
Boluoke earns its place in my regimens for biofilms and fibrin-germ nests. I start most people at 1 capsule once a day on an empty stomach, then move toward 2 times a day as tolerated. When circulation concerns are more pronounced, I have used 2 capsules two times a day. For children I follow the manufacturer scale of 1 capsule per 17 pounds of body weight per day, and only with the child’s physician involved. I stop it one week before any planned surgery and restart only with the surgeon’s agreement. I do not combine it with other enzyme supplements, since the manufacturer warns other enzymes can break lumbrokinase down. People on blood thinners or anti-platelet medicines review it with their prescribing physician first. When temporary reactions come up after starting, I hold the dose steady or step back before climbing again.
This reflects Dr. Ross's clinical experience and is educational, not medical advice. Work with your treating physician before starting, stopping, or changing any supplement or medication.
The Research, in Dr. Ross's Words
Lumbrokinase has one of the cleaner mechanistic research bases in this category. The original 1990 paper by Mihara and colleagues isolated the fibrin-dissolving enzymes from Lumbricus rubellus and showed they break down fibrin on both plasminogen-rich and plasminogen-free plates, which means the enzymes act on fibrin directly rather than through the body’s plasmin system. Later proteomic work confirmed the specific enzymes responsible and their high fibrinolytic activity.
A 2023 study adds a useful detail. In that study, lumbrokinase prevented intra-abdominal adhesions by inhibiting fibroblast migration, again without converting plasminogen into plasmin, a point the authors raise. A 2024 review of earthworm-derived bioactive agents summarizes the fibrinolytic and antithrombotic properties reported across the literature, and a review of recombinant production methods shows how much effort goes into making this enzyme reliably. That tells me the activity is real and reproducible. It does not tell me how well it performs in sick patients.
What the published papers do not yet give us is strong controlled human trial data in the chronic conditions my patients care about. The newer clinical trials in post-treatment Lyme and related conditions are still underway. In my read of this research, the enzyme science is solid, the plasminogen-independent action is a point in its favor, and the clinical outcomes remain to be proven. That is exactly how I present it to patients.
References
From:
Canada RNA
Boluoke® (lumbrokinase) is the only fully researched oral enzyme on the market supporting a healthy blood state, and it shows great promise in supporting a healthy circulation in the body. Coagulation system is a complicated and highly regulated system. For most people, Boluoke® can support the body in keeping the system in a more balanced state.
Directions of Use
The suggested dosage is 1-2 capsules one to three times daily on an empty stomach, or as directed by a health care practitioner. The capsules used in Boluoke® are acid-resistant capsules designed to resist stomach acid and dissolve in the small intestines, because lumbrokinase may be inactivated by stomach acid.
Does not contain
corn
crustacean-shellfish
eggs
fish
gluten
milk
peanuts
soy
tree-nuts
wheat
Consult your physician before taking this product or any other health supplement, especially if you are on any prescription medicine, are pregnant, have bleeding risks or having surgery. People with known allergy to lumbrokinase should not take this product. Contra-indications: allergy to lumbrokinase or earthworm; recent surgery; pre-surgery; lumbar puncture or arterial puncture; trauma; high risk aneurysm; active internal bleeding or GI ulceration; any other bleeding disorders or tendencies. Boluoke® has been shown not to significantly affect PT and aPTT (thus it does not affect INR). However, physicians and patients should be aware that other lumbrokinase products may significantly affect PT and/or aPTT. Because Boluoke® can affect platelet aggregation, it should be used cautiously with strong anti-platelets like Plavix or Ticlid and only under the supervision of a physician. The conservative approach is to stop Boluoke® 1 week prior to surgery. The patient may resume taking Boluoke® 15 days after surgery if there is no complication, or earlier if the physician deems appropriate. Keep out of the reach of children.
Excerpted from Canada RNA's product information. These statements have not been evaluated by the Food and Drug Administration.
Supplement Facts
Serving Size: 1 Capsule
Servings Per Container: 60
| Amount Per Serving | Amount | |
|---|---|---|
Proprietary earthworm protein extract Containing 300,000 LK units | 20 mg | |
*Daily Value not established. | ||
Common Questions about Boluoke
Answers are general educational information, not medical advice for your situation.
Boluoke
By Canada RNA
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