Tri-Fortify

ongoing support
Energy & Fatigue
Herx & Cytokine Support
Muscle Recovery
Nervous System & Stress
Pain Support
System Cleanse
A liposomal reduced glutathione with vitamin C from Researched Nutritionals, designed for better absorption. Supports antioxidant defenses, healthy detoxification, and immune function.
Pros
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Liposomal glutathione for daily antioxidant and detox support
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Stable at room temperature with a two year shelf life
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Oral option when IV or nebulized glutathione is not practical
Cons
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Contains soy-derived phospholipids and coconut ingredients
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Occasional separation occurs, shake well before each dose
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$66.98

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From

$66.98

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Pros
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Liposomal glutathione for daily antioxidant and detox support
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Stable at room temperature with a two year shelf life
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Oral option when IV or nebulized glutathione is not practical
Cons
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Contains soy-derived phospholipids and coconut ingredients
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Occasional separation occurs, shake well before each dose
Quick Facts
Key Ingredients
Calories 30
Total Fat 1 g
Third-party Testing
Dietary
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GMO-free
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Vegan
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Written by
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Dr. Marty Ross, MD
Updated
October 7, 2026
On This Page
Dr. Ross's Take
How Dr. Ross Uses It
The Research
References
Manufacturer's Description
Common Questions
Reviews

Dr. Ross's Expert Review

Tri-Fortify is the liposomal glutathione I use most in my practice. Glutathione is the master detoxification chemical the liver uses to remove toxins, and one of the body’s central antioxidants. The problem with most oral glutathione is that the digestive tract breaks it down before much of it is absorbed. Researched Nutritionals solves this by wrapping reduced glutathione in a phospholipid liposome, with a small amount of vitamin C, so the glutathione survives digestion and is delivered into cells.

I use it for ongoing antioxidant and detoxification support, especially in people whose bodies are under a heavy oxidative load. It also supports healthy immune function, which matters to me in anyone managing a long recovery.

There is real research behind this specific formula. In a short published trial of this product, oral liposomal glutathione raised body stores of glutathione and increased natural killer cell activity while a urinary marker of oxidative stress went down, as Sinha and colleagues reported in 2018.

The practical side is simple. Take one packet or one teaspoon, hold it under the tongue for 30 to 60 seconds, then swallow. Shake well before each dose and keep the tube on its side, because occasional separation happens. The phospholipids come from soy and the medium chain triglycerides from coconut, so anyone with soy or tree nut allergies reviews the label first, and pregnancy or nursing calls for a physician’s review too.

For a stable, good tasting oral glutathione that survives digestion, this is the one I reach for.

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. Dr. Ross has a financial relationship with the Femologist store, where this product is sold.

How I Use It in My Practice

I use Tri-Fortify as an ongoing daily support product. My typical dose is one packet or one teaspoon (5 mL) once a day, held under the tongue for 30 to 60 seconds before swallowing. In some of my patients I use it two times a day for a short stretch when detox demands are higher, then return to once a day. Shake well before each dose and keep the tube on its side between uses to limit separation. I often pair it with a binder and good hydration as part of a basic daily detox routine. Anyone on prescription medications, or who is pregnant or nursing, reviews timing and dose with their treating physician first.

This reflects Dr. Ross's clinical experience and is educational, not medical advice. Work with your treating physician before starting, stopping, or changing any supplement or medication.

The Research, in Dr. Ross's Words

The science here starts with the formula’s own trial. Sinha and colleagues gave healthy adults this liposomal glutathione and measured higher body stores of glutathione, increased natural killer cell activity, and a decrease in a urinary oxidative stress marker.

Two other trials looked at ordinary oral glutathione. In a six month randomized controlled trial, Richie and colleagues found that daily doses of 250 mg and 1,000 mg raised blood glutathione and lowered an oxidative stress biomarker. Allen and Bradley, in a trial in healthy adults, saw no significant change in oxidative stress biomarkers with oral glutathione, a candid counterpoint that people with adequate stores may see little improvement.

On the immune side, Droege and Breitkreutz’s review describes how lymphoid cells are sensitive to intracellular glutathione, with even moderate changes affecting lymphocyte function. The added vitamin C fits with Carr and Maggini’s review of vitamin C’s role in supporting both innate and adaptive immune function.

Taken together, the evidence supports oral glutathione, and liposomal delivery in particular, as a way to raise body stores, with immune and oxidative stress markers following in some but not all studies, particularly when starting stores are low.

References
From:
Researched Nutritionals
Tri-Fortify® is a clinically researched liposomal glutathione formula designed to deliver superior intracellular absorption. Tri-Fortify® utilizes an advanced liposomal delivery system that protects the glutathione through digestion and enhances delivery directly into cells where it is needed most. Tri-Fortify® is the only liposomal glutathione with a proven 24-month room temperature shelf life, requiring no refrigeration while maintaining potency and stability.
Directions of Use
As a dietary supplement, gently squeeze the tube to fill 1 teaspoon (5 mL). Hold under tongue for 30-60 seconds, and then swallow or use as directed by your health care professional. Additional doses may be taken. Shake well before use. For best results, place tube on side during storage and shake well before use, as occasional separation may occur.
Does not contain
crustacean-shellfish
eggs
fish
gluten
milk
peanuts
wheat
If pregnant or nursing, consult your health care professional before use. Contains: Ingredients partially derived from soy and tree nuts (coconut). Proposition 65 Warning for California Consumers: This product contains herbs and / or minerals which come from the soil. As such, it may contain small amounts of naturally occurring chemicals. CA WARNING: Can expose you to lead, a reproductive toxicant. See www.P65Warnings.ca.gov/foods-and-beverages
Excerpted from Researched Nutritionals's product information. These statements have not been evaluated by the Food and Drug Administration.
Supplement Facts
Serving Size: 1 packet (5 mL)
Servings Per Container: 20
Amount Per ServingAmount% DV
Calories
30
Total Fat
1 g1%
Vitamin C
Ascorbic Acid
50 mg56%
Reduced Glutathione
450 mg†
†Daily Value not established.
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    Tri-Fortify Liposomal Glutathione Watermelon flavor supplement box with packets

    Common Questions about Tri-Fortify

    Answers are general educational information, not medical advice for your situation.
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    Tri-Fortify
    By Researched Nutritionals
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