Quick Facts

Dr. Marty Ross, MD
Dr. Ross's Expert Review
Tri-Fortify is the liposomal glutathione I use most in my practice. Glutathione is the master detoxification chemical the liver uses to remove toxins, and one of the body’s central antioxidants. The problem with most oral glutathione is that the digestive tract breaks it down before much of it is absorbed. Researched Nutritionals solves this by wrapping reduced glutathione in a phospholipid liposome, with a small amount of vitamin C, so the glutathione survives digestion and is delivered into cells.
I use it for ongoing antioxidant and detoxification support, especially in people whose bodies are under a heavy oxidative load. It also supports healthy immune function, which matters to me in anyone managing a long recovery.
There is real research behind this specific formula. In a short published trial of this product, oral liposomal glutathione raised body stores of glutathione and increased natural killer cell activity while a urinary marker of oxidative stress went down, as Sinha and colleagues reported in 2018.
The practical side is simple. Take one packet or one teaspoon, hold it under the tongue for 30 to 60 seconds, then swallow. Shake well before each dose and keep the tube on its side, because occasional separation happens. The phospholipids come from soy and the medium chain triglycerides from coconut, so anyone with soy or tree nut allergies reviews the label first, and pregnancy or nursing calls for a physician’s review too.
For a stable, good tasting oral glutathione that survives digestion, this is the one I reach for.
How I Use It in My Practice
I use Tri-Fortify as an ongoing daily support product. My typical dose is one packet or one teaspoon (5 mL) once a day, held under the tongue for 30 to 60 seconds before swallowing. In some of my patients I use it two times a day for a short stretch when detox demands are higher, then return to once a day. Shake well before each dose and keep the tube on its side between uses to limit separation. I often pair it with a binder and good hydration as part of a basic daily detox routine. Anyone on prescription medications, or who is pregnant or nursing, reviews timing and dose with their treating physician first.
The Research, in Dr. Ross's Words
The science here starts with the formula’s own trial. Sinha and colleagues gave healthy adults this liposomal glutathione and measured higher body stores of glutathione, increased natural killer cell activity, and a decrease in a urinary oxidative stress marker.
Two other trials looked at ordinary oral glutathione. In a six month randomized controlled trial, Richie and colleagues found that daily doses of 250 mg and 1,000 mg raised blood glutathione and lowered an oxidative stress biomarker. Allen and Bradley, in a trial in healthy adults, saw no significant change in oxidative stress biomarkers with oral glutathione, a candid counterpoint that people with adequate stores may see little improvement.
On the immune side, Droege and Breitkreutz’s review describes how lymphoid cells are sensitive to intracellular glutathione, with even moderate changes affecting lymphocyte function. The added vitamin C fits with Carr and Maggini’s review of vitamin C’s role in supporting both innate and adaptive immune function.
Taken together, the evidence supports oral glutathione, and liposomal delivery in particular, as a way to raise body stores, with immune and oxidative stress markers following in some but not all studies, particularly when starting stores are low.
References
Supplement Facts
| Amount Per Serving | Amount | |
|---|---|---|
Calories | 30 | |
Total Fat | 1 g | |
Vitamin C Ascorbic Acid | 50 mg | |
Reduced Glutathione | 450 mg | |
†Daily Value not established. | ||



